Endocrine Abstracts

Objective: Large response of steroids precursors, including 17-hydroxyprogesterone and 11-deoxycortisol, to ACTH has been described in adrenocortical tumors, suggesting the existence of intra-tumoral enzymatic deficiencies. This study aimed to compare steroidogenic enzymes activity in unilateral and bilateral benign tumors using serum steroid profiling in HPLC-MS/MS in basal state and after ACTH 1-24 stimulation.Design and Methods: A serum profile of sev...

Introduction: The gold standard for insulinoma diagnosis is still 72-hours fasting trial with the aim to trigger Whipple’s triad. In this context, biological diagnosis of endogenous hyperinsulinism relies on the occurrence of a hypoglycemia, concomitant with inadequate high insulin and C-peptide levels. However, diagnostic cut-offs are not consensual among the different learned societies (Endocrine Society 2009, NANETS 2010, ENETS 2012). The objective of this wor...

Introduction: Adrenal steroidogenesis is alterated in adrenocortical tumors (ACT), leading frequently to abnormal steroid secretion. The development of steroid assays by mass spectrometry (MS) has greatly advanced the characterization of these alterations. However, steroid profiles are classically performed in blood and urine, providing a limited insight into adrenal steroidogenesis, altered by the mixing with gonadal steroids and by the steroid peripheral catabolism. The obje...